PREDICTABILITY OF BRACHIORADIALIS REFLEXOMETRY

 Two targets of normality were developed; RMR change >350 kcals. and Fire - Prefire intervals < 66 msecs. People that achieved the RMR (gold standard)  target  had a mean RMR measured at 2040.7 kcals. Therefore the RMR norm for euthyroid individuals was considered to be > 2000 kcals.

There were 179 people in the subpopulation of patients on no medication. There were 117 people identified as positive (hypothyroid) by RMR criteria and 123 people identified as positive by Reflex criteria. There were 58 people identified as negative (euthyroid) by RMR criteria and 57 people identified as negative by Reflex criteria. These numbers allow the construction of the following table:

 

Gold Standard (RMR) (+)

Gold Standard (RMR) (-)

Positive Test (BR)

True Positives (117)

False Positives (6)

Negative Test (BR)

False Negatives (1)

True Negatives (58)

 Sensitivity is the proportion of those that are hypothyroid that are correctly diagnosed. It is expressed as:

           ________True Positives_______    =   __117__  = 0.992

            True Positives + False Negatives          117 + 1                  

 Specificity is the proportion of those that are euthyroid that were correctly identified. It is expressed as:

            ________True Negatives_______  =   ___58___ = 0.906

            True Negatives + False Positives            58 + 6                

 Predictive Value of a Positive Test is the proportion of those with a positive test that are hypothyroid. It is expressed as:

            ________True Positives_______   =   ___117__  =  0.951

            True positives + False Positives                  117+6                    

 Predictive Value of a Negative Test can be considered as the proportion of those with a negative test that are hypothyroid; which is expressed as:

            _______False Negatives_______    =  _____1____  =  0.017

            False Negatives + True Negatives             1 + 58                      

 More commonly Predictive Value of a Negative Test is considered the proportion of those with a negative test who are euthyroid: which is expressed as:

            _______True Negatives_______   =    ___58___  =  0.983

              False Negatives + True Negatives           1 + 58